Dushkin Alexandr Valerevich
Institute of Solid State Chemistry SB RAS, Russia
Biography
Dushkin A V Educational background: 1972 – Novosibirsk State University, Department of Chemistry; 1977 - Ph.D; Institute of Chemical Kinetics and Combustion, Novosibirsk, Russia; 2006 -Doctor of chemical sciences, State University of Chemical Technology, Ivanovo, Russia; 2008-2018 – Professor, Correspondent member, Academician of Russia’s Academy of Natural History. Institutional Affiliations: 1986 - present – Institute of Solid State Chemistry, Novosibirsk, Russia, Heading researcher, Head of scientific group. ~ 380 publications Research Interests: Supramolecular Chemistry, Mechanochemistry, Drug Delivery
Abstract
Newest results of application areas and advantages of mechano chemical technology of drug modification are considered. The main approach for pharmacy is based on preparation of solid disperse systems of pharmaceutics substances with different auxiliaries oligo and polysaccharide, plant’s saponins, synthetic polymers, amorphous silica substances. After dissolution in water they form supramolecular nanoscale formations such as inclusion complexes, micelles and nanoparticles which containing drug molecules as «guest-host» types. Noted processes provide sufficiently increase of solubility, bioavailability and pharmacology action (lowering of meaning doses in 2-100 folds) of drug. Examples of drugs investigated