Targeted drug delivery: Advances and Approaches
Targeted drug delivery is a kind of drug delivery, a method of delivering medication to a patient in a manner that increases the concentration only in particular area of the body. The goal of a targeted drug delivery system is to prolong, localize and have a safe drug interaction with the diseased tissue. The advantages of the this drug delivery are 1. reduction in the frequency of the dosages taken by the patient 2. have an uniform effect of the drug, 3.reduction of drug side-effects 4. reduce fluctuation in circulating drug levels 5.maintain the optimum plasma and tissue drug levels in the body. A small portion of the medication reaches the affected organ in Chemotherapy and roughly 99% of the administered drug does not reach the tumor site.
The following criteria must be taken into consideration while designing a targeted drug delivery: the drug property,the route of drug delivery, the targeted site, disease and the side effects of drug. There are two kinds- active targeted drug delivery such as antibody medications and passive targeted drug deliver such as the enhanced permeability and retention effect.