Targeted Drug Delivery System: Advances and Approaches
Targeted drug delivery is a kind of smart drug delivery, a method of delivering medication to a patient in a manner that increases the concentration only in particular part of the body. The goal of a targeted drug delivery system is to prolong, localize and have a protected drug interaction with the diseased tissue. The advantages of the targeted drug delivery are 1. reduction in the frequency of the dosages taken by the patient 2. have a more uniform effect of the drug, 3.reduction of drug side-effects 4. reduce fluctuation in circulating drug levels 5.maintain the required plasma and tissue drug levels in the body. In chemotherapy only a small portion of the medication reaches the affected organ and roughly 99% of the administered drug does not reach the tumor site.
While designing a targeted drug delivery, the following criteria must be taken into consideration: the drug properties, the route of drug delivery, the targeted site, disease and the side effects of drug. There are two kinds of targeted drug delivery: active targeted drug delivery, such as antibody medications, and passive targeted drug delivery, such as the enhanced permeability and retention effect.